pentobarbital will lessen the extent or influence of artemether/lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducers may lead to reduced serum concentrations and lack of antimalarial efficacy
pentobarbital will lower the extent or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Reserve concomitant prescribing of those drugs in individuals for whom other therapy selections are inadequate. Restrict dosages and durations to your minimum essential. Watch intently for indications of respiratory depression and sedation.
pentobarbital will enhance the stage or impact of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers lessened ivosidenib plasma concentrations.
pentobarbital will decrease the level or influence of bazedoxifene/conjugated estrogens check here by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Contraindicated. Coadministration of doravirine with a solid CYP3A inducer might lessen doravirine plasma concentrations and/or effects. Prospective for lack of virologic reaction and achievable resistance to doravirine.
Contraindicated (1)pentobarbital will decrease the level or effect of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration. Potent or average CYP3A inducers could decrease cobimetinib systemic publicity by >80% and lower its efficacy.
pentobarbital boosts toxicity of methoxyflurane by raising metabolism. Contraindicated. Greater metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will lower the level or impact of etonogestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Elderly or debilitated individuals may possibly react to barbiturates with marked melancholy, exhilaration, and confusion; in a few patients, barbiturates continuously make excitement rather than melancholy
Caution with use for the duration of surgical procedures or processes in small children younger than 3 yr or in Expecting Females through their third trimester
pentobarbital will lower the extent or impact of loratadine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the level or impact of parecoxib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
pentobarbital will lower the level or result of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.